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Updated: Aug 19, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Expression of cyclin D1 and p53 protein in various malignant skin tumors
S Inohara1, K Kitagawa, Y Kitano
1Department of Dermatology, Hyogo College of Medicine, Japan.
Background:
Overexpression of cyclin D1 and p53 protein has been reported in many types of malignant tumors.
Objectives:
We investigated whether cyclin D1 was detected immunohistochemically in various types of malignant tumors of the skin, comparable with p53 protein.
Methods:
Immunohistochemical staining of cyclin D1 and p53 protein was applied to squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma and various kinds of benign skin tumors.
Results:
Cyclin D1 was positive only in malignant tumors at the same incidence as p53 protein.
Conclusion:
Cyclin D1 immunohistochemical staining may be a malignant marker for various skin tumors.
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