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Efficacy of quinolones in preventing Staphylococcus aureus-induced abscess in mice
M A Cohen1, J W Gage, M D Huband
1Infectious Diseases Section, Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105-2495, USA.
The Journal of Antimicrobial Chemotherapy
|September 1, 1995
Abstract:
The new fluoroquinolones clinafloxacin, CI-990 (PD 131112/PD 131628), sparfloxacin, and PD 138312 were bactericidal against Staphylococcus aureus with MICs > or = 4-fold lower than ciprofloxacin values. In a murine subcutaneous abscess model (subcutaneous/oral dosing) the new drugs displayed protective activities against five strains which were generally higher (up to 19-fold) than ciprofloxacin values.