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[Hyperthermia and palliative radiotherapy for sarcoma]

M Amichetti1, C Graiff, M Romano

  • 1Divisione di Radioterapia Oncologica, Ospedale S. Chiara, Trento.

La Radiologia Medica
|June 1, 1996
PubMed
Summary

Combining radiotherapy with hyperthermia shows promise for treating recurrent or locally advanced sarcomas, offering significant response rates with mild toxicity. This approach may improve local control and survival outcomes.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Bone and soft tissue sarcomas often recur locally, necessitating improved treatment strategies.
  • Current multimodality treatment (surgery, radiotherapy, chemotherapy) has limitations in preventing local recurrence.
  • Hyperthermia is explored as an adjunct to radiotherapy to enhance local tumor control.

Purpose of the Study:

  • To evaluate the efficacy and toxicity of combining radiotherapy with hyperthermia for patients with recurrent or locally advanced sarcomas.
  • To identify factors influencing treatment response in this patient cohort.

Main Methods:

  • A retrospective study of 12 patients (15 lesions) treated between 1982 and 1993.
  • Treatment involved radiation therapy (24-70 Gy) combined with local microwave hyperthermia (2-9 sessions).

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  • Response rates, local control, overall survival, and toxicity were assessed.

    • Main Results:

    • A high objective response rate was observed: 53.3% complete responses and 26.6% partial responses.
    • Five-year actuarial local control was 25.4% +/- 13.4%, with 5-year overall survival at 49.5% +/- 16.4%.
    • Mild toxicity was noted, primarily superficial necroses and transient pain during hyperthermia.

    Conclusions:

    • The combination of radiotherapy and hyperthermia appears to be a valuable therapeutic option for locally advanced or recurrent sarcomas.
    • Lesion volume and total radiation dose were correlated with treatment response.
    • Further investigation into this combined modality approach is warranted.