Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

XYY male and hematologic malignancy

N Oguma1, C Shigeta, N Kamada

  • 1Department of Cancer Cytogenetics, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan.

Cancer Genetics and Cytogenetics
|September 1, 1996
PubMed
Summary

This study reviewed 26 cases of XYY males with hematologic malignancies. Evidence suggests XYY males developing blood cancers is likely coincidental, not genetically caused.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibitory effect of polysulfide, an endogenous sulfur compound, on oxidative stress-induced TRPA1 activation.

Neuroscience letters·2021
Same author

The Bacterial Connection between the Oral Cavity and the Gut Diseases.

Journal of dental research·2020
Same author

Citrobacter rodentium Induces Tissue-Resident Memory CD4<sup>+</sup> T Cells.

Infection and immunity·2019
Same author

A specific gene-microbe interaction drives the development of Crohn's disease-like colitis in mice.

Science immunology·2019
Same author

Unique Raman Spectroscopic Fingerprints of B-Cell Non-Hodgkin Lymphoma: Implications for Diagnosis, Prognosis and New Therapies.

Journal of biological and medical sciences·2018
Same author

Transplantation tolerance and immunosuppression following liver grafting in rats.

Immunology today·2014

Area of Science:

  • Genetics
  • Hematology
  • Oncology

Background:

  • Review of XYY males diagnosed with hematologic malignancies.
  • Analysis of 26 reported cases including various leukemia types and myelodysplastic syndromes.

Observation:

  • Two new cases of XYY males with refractory anemia with excess of blasts presented.
  • Age at diagnosis ranged from 7.5 to 81 years.
  • In mosaic cases, the XYY clone was sometimes associated with malignancy, but not always.

Findings:

  • The overall incidence of hematologic malignancy in XYY males appears incidental.
  • No direct genetic etiology linking XYY karyotype to blood cancers was identified.

Implications:

  • Findings suggest XYY karyotype is not a predisposing factor for hematologic malignancies.
  • Further research may explore other contributing factors in XYY males who develop blood cancers.

Related Experiment Videos