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Related Experiment Video

Updated: Jul 27, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

[Autoantibodies in bronchial asthma]

K Fujimori¹, E Suzuki, M Arakawa

¹Department of Internal Medicine, Niigata Prefectural Shibata Hospital.

Arerugi = [Allergy]

|July 1, 1996

Summary

Non-atopic asthma patients show a higher prevalence of antinuclear antibodies (ANA) compared to atopic asthma patients. This suggests a potential autoimmune link in non-atopic asthma, possibly due to infections and inflammation.

Area of Science:

Immunology
Pulmonology
Autoimmunity

Context:

Asthma is a heterogeneous respiratory condition with distinct atopic and non-atopic phenotypes.
Autoantibodies are implicated in various autoimmune and inflammatory diseases.
Understanding autoantibody prevalence can differentiate asthma subtypes and inform pathogenesis.

Purpose:

To investigate the difference in autoantibody prevalence between atopic and non-atopic asthma.
To compare antinuclear antibody (ANA) incidence across asthma subtypes, lung cancer, and control groups.

Summary:

The study evaluated antinuclear antibodies (ANA) in 20 atopic asthma, 15 non-atopic asthma, 20 lung cancer patients, and 103 controls using indirect immunofluorescence.
Positive ANA was detected in 4/20 atopic asthma, 8/15 non-atopic asthma, 6/20 lung cancer, and 12/103 controls.

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Significantly higher ANA incidence was observed in non-atopic asthma compared to atopic asthma, irrespective of age or sex.

Impact:

Findings suggest a higher propensity for autoantibody development in non-atopic asthma.
Hypothesizes that viral infections and chronic airway inflammation in non-atopic asthma may impair lymphocyte surveillance, promoting autoimmunity.
Highlights potential differences in the immunological underpinnings of atopic versus non-atopic asthma.