[Splitting of fructose diphosphate by muscle and tumor homogenates]

Effect of MgCl2 and ATP on the elevation in lactate, pyruvate and methylglyoxale content was studied on incubation of fructosediphosphate with muscle and tumor homogenates. Muscle homogenate accumulated lactate, pyruvate and methyglyoxale more intensively as compared with tumor homogenate. Pyruvate was formed only in presence of MgCl2 and ATP, although it did not practically affect the elevation of lactate in muscle homogenate. The data obtained suggest that tumor homogenate does not contain the enzymatic system involved in methylglyoxale formation.