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HPLC and GLC determination of residual solvents in busulphan
O I Kalchenko1, V A Golub, I V Zavatskaja
1Institute of Organic Chemistry, Ukrainian Academy of Sciences, Kiev.
Journal of Pharmaceutical and Biomedical Analysis
|December 1, 1995
Abstract:
Quantitative methods using HPLC and GLC for the determination of residual pyridine and ethanol in busulphan have been developed. The measurement errors for pyridine and ethanol in busulphan samples (p = 0.95) were found to be 10% and 7%. It was shown that one recrystallization enabled pure busulphan to be prepared.