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Skeletal muscle pathology in systemic sclerosis
E E Calore1, M J Cavaliere, N M Perez
1Anatomia Patológica, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil.
The Journal of Rheumatology
|December 1, 1995
Abstract
Objective:
Systemic sclerosis (SSc) is characterized by abnormal deposition of collagen in the skin and by visceral involvement. Muscle weakness is a relatively frequent complication of SSc, although severity varies. We studied muscle pathology in patients with SSc with progressive muscle involvement.
Methods:
We performed histochemical and immunohistochemical investigations to detect neural cell adhesion molecule (NCAM).
Results:
Five of the 6 cases of SSc expressed NCAM in atrophic angulated fibers (some fibers stained heavily with oxidative enzymes).
Conclusion:
Neurogenic involvement in SSc is more frequent than reported.