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Accelerated nodulosis in a patient with psoriasis and arthritis during treatment with methotrexate
B Berris1, J B Houpt, J Tenenbaum
1Department of Medicine, Mount Sinai Hospital, University of Toronto, Canada.
The Journal of Rheumatology
|December 1, 1995
Abstract:
A 66-year-old woman with longstanding psoriasis involving the skin presented with asymmetrical polyarthritis. Methotrexate (MTX) was given initially intramuscularly and orally. Intramuscular MTX was discontinued, and a few months after she had been taking only oral MTX she developed nodules, first in surgical incisions, and subsequently in her buttocks, thighs, legs, and arms. Reduction of the dose of oral MTX was followed by gradual diminution in size of the nodules and then total disappearance.