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Cyclic ADP-ribose and calcium signaling in eggs
1Department of Physiology, University of Minnesota, Minneapolis 55455, USA.
Biological Signals
|March 1, 1996
Abstract:
Cyclic ADP-ribose is a cyclic nucleotide with Ca2+ signaling functions. It was first discovered in sea urchin eggs and has since been shown to be active in a variety of cells. Another Ca2+ release mechanism recently described in the eggs is mediated by nicotinic acid dinucleotide phosphate, a derivative of NADP+. This article summarizes current results on these two novel Ca(2+)-mobilizing pathways that are independent of inositol trisphosphate.