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Corticosteroid and immune responses to cardiac surgery
A A Tinnikov1, M V Legan, N A Sheveluk
1Institute of Cytology and Genetics, Novosibirsk, Russia. tinnikov@cgi.nsk.su
Steroids
|July 1, 1996
Summary
Cardiac surgery impacts hormone and immune cell levels. Open heart surgery significantly decreases corticosteroid-binding globulin (CBG) and immunocompetent cells (ICCs), while cortisol levels rise.
Area of Science:
- Cardiology
- Endocrinology
- Immunology
Background:
- Cardiac surgery involves significant physiological stress.
- Hormonal and cellular immune responses are critical during surgical procedures.
Purpose of the Study:
- To investigate the changes in serum corticosteroid-binding globulin (CBG), cortisol, and circulating immunocompetent cells (ICCs) during different types of cardiac surgery.
- To differentiate the impact of closed versus open heart surgery on these physiological markers.
Main Methods:
- Measurements of serum CBG and cortisol levels.
- Quantification of circulating immunocompetent cell (ICC) subsets.
- Analysis during closed mitral commissurotomy and open heart surgery with surface-induced hypothermia.
Main Results:
- Closed heart surgery led to elevated cortisol levels without affecting CBG or ICCs.
- Open heart surgery with hypothermia caused a significant decrease in CBG and ICCs.
- Cortisol levels showed a delayed and less pronounced increase during open heart surgery compared to closed surgery.
Conclusions:
- Open heart surgery, particularly with hypothermia, induces substantial alterations in CBG and ICC levels, suggesting a significant immune and endocrine response.
- The type of cardiac surgery influences the magnitude and pattern of hormonal and cellular immune changes.