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[Curable ECHO 5 virus encephalitis. Clinical, electroencephalographic, virologic and ultrastructural study]
Annales De Medecine Interne
|April 1, 1977
Summary
A boy experienced severe encephalitis caused by ECHO 5 virus, leading to coma and neurological symptoms. Full recovery occurred after six years, confirmed by viral isolation and ultrastructural analysis.
Area of Science:
- Pediatric Neurology
- Virology
- Neuroscience
Background:
- Encephalitis is a serious inflammation of the brain, often caused by viral infections.
- Early diagnosis and understanding the causative agent are crucial for patient outcomes.
Observation:
- A 10-year-old boy presented with acute neurological deterioration, including seizures, confusion, coma, fever, and rash.
- Neurological sequelae included transient Parkinsonism and persistent myoclonus for six months.
- Electroencephalogram (EEG) showed characteristic repetitive sharp wave bursts, suggesting encephalitis.
Findings:
- ECHO 5 virus was isolated from a brain specimen, confirming the viral etiology.
- Ultrastructural examination revealed cytopathic effects in astrocytes, such as organelle disappearance and membrane proliferation.
- Viral particles were observed within astrocytes, indicating direct viral involvement without significant inflammation.
Implications:
- This case highlights ECHO 5 virus as a cause of severe encephalitis in children.
- Ultrastructural findings provide insights into thePathogenesis of viral encephalitis at the cellular level.
- Long-term follow-up confirmed complete recovery, underscoring the potential for favorable outcomes in some viral encephalitis cases.