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Updated: Aug 10, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
Published on: June 10, 2020
Cerebral infarction and intracranial arterial dissection in closed head injury
G S Rutherfoord1, M A Dada, J P Nel
1Neuropathology Unit, University of Stellenbosch, Cape Town, South Africa.
Insights
Autopsy revealed subintimal dissection of intracranial arteries caused cerebral infarction in three head injury cases. Histological examination is crucial for diagnosing these vascular lesions.
Area of Science:
- Neuropathology
- Vascular Pathology
- Traumatic Brain Injury
Background:
- Closed head injuries can lead to severe neurological complications.
- Cerebral infarction, brain swelling, and herniation are critical outcomes.
- Vascular injury is a potential, though often overlooked, cause of infarction post-trauma.
Abstract:
This report describes the autopsy findings in three cases of closed head injury dying of cerebral infarction, with brain swelling and herniation. In each instance the cause of the infarct was found to be subintimal dissection involving intracranial anterior circulation arteries. The autopsy findings underscore the value of histological examination of vessels that macroscopically appear thrombosed. We discuss factors that impact on the reported incidence and make brief mention of problems surrounding the true pathogenesis of this lesion.
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