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Updated: Aug 6, 2026

Quantifying Glomerular Permeability of Fluorescent Macromolecules Using 2-Photon Microscopy in Munich Wistar Rats
Published on: April 17, 2013
[Selective permeability of the glomerular filtration barrier in man]
P Petitjean1, F Chantrel, T Hannedouche
1Département de néphrologie, Hôpitaux Universitaires de Strasbourg.
Abstract:
Glomerular ultrafiltration of macromolecules is a biophysical process sharing both a diffusive and a convective component, governed by glomerular hemodynamics, through a composite structure, the glomerular filtration barrier. Studies of the fractional clearance of macromolecules have showed that transcapillary filtration of macromolecules is hindered by size, electrostatic charge and to a lesser degree by spatial conformation. Several modelizations of ultrafiltration have been developped to quantify the respective role of glomerular hemodynamic and/or membrane structural alternations as found in glomerular diseases.
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