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Screening of the macromolecular component of CSF from various pathologies for its interference with GABAA receptor
M V Rapallino1, A Cupello, A Leonardi
1Centro di Neurofisiologia Cerebrale, CNR, Genova, Italy.
Italian Journal of Neurological Sciences
|December 1, 1995
Abstract:
Cerebrospinal fluid (CSF) samples from patients undergoing lumbar puncture for suspected neurological diseases were fractioned into macromolecular (MW > 3000 Daltons) and small molecule components (MW < 3000 Daltons). The macromolecular component was tested for its interference with GABA stimulation of 36Cl- accumulation in rat cerebral cortex microsacs. For many pathologies, no interference was apparent; an exception was two patients with Parkinson's disease in whom there were clear signs of stimulated GABA activity. This last result seems worthy of further investigation.