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Pentoxifylline in male-factor infertility: its therapeutic efficacy after oral administration
Objective:
To determine whether the oral use of pentoxifylline improves the fertilization ability, concentration and motility of spermatozoa of poor fertilizer male subject.
Design:
Analysis of the spermiogram parameters before and after oral pentoxifylline administration.
Setting:
Zeynep Kamil Women and Children's Hospital, Department of Infertility.
Patients:
Fourteen healthy, untreated male partners of couples who applied to our infertility department and were found to have poor semen parameters.
Main Outcome Measures:
Data of the semen analyses and fertilization rates are compared before and after treatment.
Results:
Before the treatment, the average percentage sperm motility and density were 30.1 +/- 8 (%) and 14.8 +/- 3.2 (10(6)/ml), respectively. The same parameters were found to be 37.8 +/- 13 (%) and 19.5 +/- 10 (10(6)/ml), respectively, following the treatment. Not significant, p = 0.08 and p = 0.116, respectively).
Conclusion:
None of the semen parameters evaluated were improved by oral administration of pentoxifylline. Therefore pentoxifylline does not increase percentage motility and density of spermatozoa or the fertilization rates.