Elevated amylase is related to the development of respiratory failure in organophosphate poisoning

1. A retrospective study of organophosphate (OP) poisoning in the intensive care unit was performed to analyze the incidence of respiratory failure. 2. The patients were treated initially with gastrointestinal decontamination including gastric lavage and the administration of activated charcoal with cathartic. Further management included intravenous pralidoxim and atropine and ventilatory support. 3. Of the 32 OP poisoning patients, 16 patients developed respiratory failure and received ventilatory support. 4. An increase in plasma amylase above the normal range on the day of admission was related to the development of respiratory failure. 5. In OP poisoning, the elevation of amylase level was predictive of the subsequent respiratory failure.