Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emerging issues in mouse liver carcinogenesis

J M Ward1, M A Shibata, D E Devor

  • 1Veterinary and Tumor Pathology Section, National Cancer Institute, Frederick, Maryland 21702-1201, USA.

Toxicologic Pathology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to "Regarding Mole-rats and Cancer".

Veterinary pathology·2016
Same author

Why Animals Die: An Introduction to the Pathology of Aging.

Veterinary pathology·2016
Same author

Initial Case Reports of Cancer in Naked Mole-rats (Heterocephalus glaber).

Veterinary pathology·2016
Same author

The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents.

Veterinary pathology·2016
Same author

Cause-of-Death Analysis in Rodent Aging Studies.

Veterinary pathology·2015
Same author

A rapid, sensitive colorimetric assay for the high-throughput screening of transaminases in liquid or solid-phase.

Chemical communications (Cambridge, England)·2015
Same journal

Comparison of Standard Clinical Pathology Parameter Values in Fasted and Fed Rats and Non-human Primates.

Toxicologic pathology·2026
Same journal

Time-Dependent Autolysis in Ex Vivo-Maintained Rat Tissue in Saline: A Descriptive Study and Practical Guidance for Histopathologic Assessment.

Toxicologic pathology·2026
Same journal

New Approach Methodologies (NAMs) for Carcinogenicity Evaluation.

Toxicologic pathology·2026
Same journal

2025 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: Pathology Working Groups (PWGs) in Toxicologic Pathology.

Toxicologic pathology·2026
Same journal

Toxicologic Pathology Forum*: Opportunities and Challenges in the Use of Artificial Intelligence in Nonclinical Toxicologic Histopathology Evaluations.

Toxicologic pathology·2026
Same journal

New Modalities and Carcinogenicity Assessment.

Toxicologic pathology·2026
See all related articles

Mouse liver tumors arise from various chemicals and progress through distinct stages. Distinguishing carcinogenic mechanisms by tumor appearance alone is challenging, requiring further research for accurate human cancer risk assessment.

Area of Science:

  • Toxicology
  • Hepatocarcinogenesis
  • Chemical carcinogenesis

Background:

  • Mouse liver is a primary target for over 200 carcinogenic chemicals.
  • Hepatocarcinogenesis in mice follows defined morphological stages, regardless of tumor origin (spontaneous or induced).
  • Tumor morphology can be influenced by the inducing agent and liver health.

Purpose of the Study:

  • To explore the relationship between chemical exposure, liver tumor morphology, and underlying carcinogenic mechanisms in mice.
  • To investigate the challenges in distinguishing carcinogenic pathways based on histological appearance and genetic mutations.
  • To enhance human cancer risk assessment through a better understanding of mouse liver tumor development.

Main Methods:

  • Analysis of liver tumors induced by various chemicals in long-term toxicity studies.

Related Experiment Videos

  • Morphological assessment of hepatocytes during different stages of hepatocarcinogenesis.
  • Investigation of H-ras oncogene mutations in mouse liver tumors.

    • Main Results:

    • Mouse liver tumors exhibit diverse morphological features and progression rates, influenced by the inducing chemical and liver condition.
    • Both genotoxic and non-genotoxic chemicals can induce tumors of varying malignancy.
    • Morphological similarity and H-ras mutation patterns can make distinguishing carcinogenic mechanisms difficult.

    Conclusions:

    • Liver tumor morphology and mutation spectra alone may not be sufficient to elucidate carcinogenic mechanisms.
    • Further research is needed to understand how test chemicals promote spontaneous hepatocarcinogenesis.
    • Understanding these mechanisms is crucial for improving human cancer risk evaluations.