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Recent developments in topical and transdermal delivery

J Hadgraft1

  • 1Welsh School of Pharmacy, University of Wales, Cardiff, UK.

European Journal of Drug Metabolism and Pharmacokinetics
|April 1, 1996
PubMed
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Understanding skin penetration enhancement is key for drug delivery. Techniques like chemical enhancers, supersaturation, iontophoresis, and sonophoresis offer new ways to deliver biotech drugs and monitor levels non-invasively.

Area of Science:

  • Pharmaceutical Sciences
  • Biophysics
  • Dermatology

Background:

  • Significant interest exists in understanding skin penetration mechanisms.
  • Biophysical techniques probe molecular-level enhancement strategies.
  • Chemical and physical methods are explored for improved skin permeation.

Purpose of the Study:

  • To review advancements in skin penetration enhancement.
  • To explore methods for delivering challenging biotech drugs percutaneously.
  • To discuss non-invasive monitoring and feedback-controlled transdermal systems.

Main Methods:

  • Utilizing sophisticated biophysical techniques.
  • Investigating chemical penetration enhancers and their synergistic effects.
  • Exploring supersaturation for enhanced skin penetration.

Related Experiment Videos

  • Applying iontophoresis and sonophoresis for drug delivery.
  • Developing non-invasive percutaneous monitoring.

    • Main Results:

    • Co-administration of chemical enhancers can yield synergistic effects.
    • Supersaturation is a promising enhancement method, though stability requires attention.
    • Iontophoresis and sonophoresis enable percutaneous delivery of biotech drugs.
    • Percutaneous route allows for non-invasive plasma level monitoring.

    Conclusions:

    • Advanced techniques offer molecular-level understanding of skin penetration.
    • Novel methods facilitate the transdermal delivery of complex pharmaceuticals.
    • Integration of monitoring and delivery enables biofeedback-controlled transdermal systems.