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Vitamin E in humans: demand and delivery

M G Traber¹, H Sies

¹Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.

Annual Review of Nutrition

|January 1, 1996

Summary

Vitamin E supplementation helps prevent and treat deficiency symptoms like nerve and balance problems. For optimal health, aim for 15-30 mg of alpha-tocopherol daily to maintain healthy plasma levels.

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Area of Science:

Nutritional Science
Biochemistry
Human Physiology

Background:

Vitamin E deficiency can lead to neurological issues such as peripheral neuropathy and ataxia.
Deficiency often stems from malabsorption disorders or genetic defects affecting vitamin E transport.
Impaired delivery of vitamin E to tissues causes characteristic deficiency symptoms.

Purpose of the Study:

To outline the established uses of vitamin E supplementation in preventing and treating deficiency symptoms.
To discuss the potential role of vitamin E in managing chronic diseases and specific health conditions.
To recommend optimal daily intake levels for achieving adequate plasma concentrations in healthy individuals.

Main Methods:

Review of established therapeutic uses of vitamin E.
Discussion of vitamin E's role in various chronic diseases and conditions.
Analysis of recommended daily intake for optimal plasma levels.

Main Results:

Vitamin E is crucial for preventing and treating deficiency symptoms.
Supplemental vitamin E is considered for chronic conditions like heart disease, diabetes, and neurodegenerative disorders.
A daily intake of 15-30 mg of alpha-tocopherol is recommended for optimal plasma concentrations (≥30 microM) in healthy individuals.

Conclusions:

Vitamin E plays a vital role in preventing deficiency symptoms and may benefit various chronic health conditions.
Maintaining optimal plasma alpha-tocopherol concentrations through adequate intake is essential for overall health.
Recommended daily intake for healthy individuals is 15-30 mg of alpha-tocopherol.

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