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Case report: hippocratic digital and Crohn's disease
K Makiyama1, K Ishida, W Zea-Iriarte
1Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Journal of Gastroenterology and Hepatology
|July 1, 1996
Summary
This report details a rare case of finger clubbing and hypertrophic osteoarthropathy in a Japanese Crohn's disease patient. It highlights the potential role of platelets in these rare inflammatory bowel disease complications.
Area of Science:
- Gastroenterology
- Rheumatology
- Pathology
Background:
- Inflammatory bowel disease (IBD), including Crohn's disease, is associated with various extraintestinal manifestations.
- Finger clubbing (Hippocratic digital) and secondary hypertrophic osteoarthropathy are rare complications of IBD, more frequently reported in Western populations.
Observation:
- A case study of a 29-year-old Japanese male with Crohn's disease presenting with both finger clubbing and secondary hypertrophic osteoarthropathy.
- This represents the first reported instance of finger clubbing associated with Crohn's disease in Japan.
Findings:
- The co-occurrence of finger clubbing and secondary hypertrophic osteoarthropathy in Crohn's disease is exceptionally rare.
- The study discusses the pathogenesis, suggesting finger clubbing and hypertrophic osteoarthropathy may be part of a shared pathological spectrum.
Implications:
- The findings suggest a potential role for megakaryocytes or platelet aggregates in the development of these conditions.
- This case expands the known geographical and clinical spectrum of IBD-associated digital and skeletal changes.
- Further research into the role of platelet function in IBD complications is warranted.