Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apolipoprotein E genotype distribution in schizophrenia

S Zhu1, M M Nöthen, S Uhlhaas

  • 1Institute of Human Genetics, University of Bonn, Germany.

Psychiatric Genetics
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developmental Correlates of Epigenetic and Polygenic Indices of Cognition and Educational Attainment from Birth to Young Adulthood.

bioRxiv : the preprint server for biology·2026
Same author

Contribution of Rare and Potentially Functionally Relevant Sequence Variants in Schizophrenia Risk-Locus Xq28,distal.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics·2024
Same author

Exploring the overlap between alopecia areata and major depressive disorder: Epidemiological and genetic perspectives.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same author

Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID-19.

Skin health and disease·2021
Same author

Transcriptome-wide analysis of filarial extract-primed human monocytes reveal changes in LPS-induced PTX3 expression levels.

Scientific reports·2019
Same author

Effects of BDNF Val<sup>66</sup>Met genotype and schizophrenia familial risk on a neural functional network for cognitive control in humans.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2018
Same journal

Dissecting causal and putative mechanistic pathways from lifestyle factors to neurological diseases via the glymphatic system: a Mendelian randomization study.

Psychiatric genetics·2026
Same journal

A rare missense variant in Bruton's tyrosine kinase is associated with bipolar disorder accompanied by psychosis.

Psychiatric genetics·2026
Same journal

Identification of rare missense variants of ionotropic glutamate receptor N-methyl-D-aspartate 2 genes in patients with schizophrenia.

Psychiatric genetics·2026
Same journal

Expression and function of miR-218-5p in the pathogenesis of postpartum depression.

Psychiatric genetics·2026
Same journal

Case report of a boy with autism spectrum disorder and lysinuric protein intolerance.

Psychiatric genetics·2026
Same journal

Familial co-occurrence of autism spectrum disorder and 47 XYY syndrome: revisiting the role of Y chromosome dosage in neurodevelopment.

Psychiatric genetics·2026
See all related articles

This study investigated apolipoprotein E (apoE) isoforms in schizophrenia, finding no significant genetic association. ApoE does not appear to be a common factor in the development of Alzheimer's disease and schizophrenia.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Apolipoprotein E (apoE) isoforms are established risk factors for Alzheimer's disease (AD).
  • The potential role of apoE in schizophrenia pathogenesis remains unclear.

Purpose of the Study:

  • To investigate the hypothesis that apoE isoforms may be involved in the development of schizophrenia.
  • To determine if apoE acts as a common genetic factor in both Alzheimer's disease and schizophrenia.

Main Methods:

  • Genotyping of apolipoprotein E (apoE) in 98 schizophrenia patients and 98 matched controls.
  • Analysis of apoE allele frequencies and correlation with age at onset in patients.

Main Results:

  • No significant differences in apoE allele frequencies were found between schizophrenia patients and controls.

Related Experiment Videos

  • No association was observed between apoE genotype and age at onset in schizophrenia patients.
  • The study found no evidence supporting apoE as a common pathogenic factor for AD and schizophrenia.

    • Conclusions:

    • The findings do not support a direct association between apoE isoforms and schizophrenia.
    • Apolipoprotein E does not appear to be a shared etiological factor for Alzheimer's disease and schizophrenia.