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Factor V Leiden mutation in cerebral venous thrombosis
1Service de Neurologie, Centre R. Garcin, Hôpital Sainte-Anne, Paris, France.
Stroke
|October 1, 1996
Summary
The Factor V Leiden mutation, a common cause of inherited thrombophilia, is a significant risk factor for cerebral venous thrombosis (CVT). This inherited coagulation defect is more prevalent in CVT patients than in healthy individuals.
Area of Science:
- Genetics
- Hematology
- Neurology
Background:
- Activated protein C resistance is a known inherited risk factor for venous thrombosis.
- This resistance is caused by the factor V Leiden mutation.
- The prevalence of factor V Leiden mutation in cerebral venous thrombosis (CVT) was previously unknown.
Purpose of the Study:
- To investigate the association between the factor V Leiden mutation and CVT.
- To determine if factor V Leiden mutation is a risk factor for cerebral venous thrombosis.
Main Methods:
- A case-control study was conducted.
- Nineteen patients with CVT and 57 healthy controls were tested for the factor V mutation.
- The point mutation was identified using genetic testing.
Main Results:
- The factor V Leiden mutation was found in 21% of CVT patients versus 2% of controls (P = .02).
- This prevalence is similar to that seen in deep vein thrombosis patients.
- In mutation carriers, CVT occurred with acquired prothrombotic states like oral contraceptive use or puerperium.
Conclusions:
- The factor V Leiden mutation is a significant risk factor for CVT.
- It is likely the most common inherited coagulation defect associated with cerebral venous thrombosis.