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Lanthanide or transition metal ions-mediated cleavage of DNA by hydroxamic acid derivative
1Department of Biological Science and Technology, Science University of Tokyo, Chiba, Japan.
Nucleic Acids Symposium Series
|January 1, 1995
Abstract:
N-[5-(hydroxylaminocarbonyl)pentyl]phenanthridium chloride 1 has been shown to induce cleavage of ColE1 DNA in the presence of transition (ferrous, ferric and vanadyl) or lanthanide(III) (lutetium, thulium and europium) metal ions. The addition of free radical scavengers inhibits the former reaction, but does not the latter case.