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Synthetic study on carbocyclic analogues of cyclic ADP-ribose
1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Nucleic Acids Symposium Series
|January 1, 1995
Abstract:
Cyclic ADP-ribose (cADPR, 1) is a newly discovered general mediator involved in Ca2+ signaling. Carbocyclic analogues of 1, namely, 2 and 3, were designed as a stable isosteres of 1, and their synthesis was studied. The reaction of a triflate 9 which was derived from known diol 4, and inosine derivative 10 gave desired N1-alkyl derivative 11 in 38% yield, and then it was converted to diphosphate derivative 12.