Synthesis and properties of 2',5'-oligoadenylates containing alpha-adenosine

Alpha-Adenosine analogs of 2'-5'Oligoadenylates (alpha 2-5 A) were synthesized by uranyl ion-catalyzed oligomerization of alpha-adenosine-5'-phosphorimidazolide in aqueous solution. alpha-Anomeric 3'-5'oligoadenylates were simultaneously formed in the oligomerization reaction. Physicochemical and biochemical properties of the resulting alpha 2-5 A were studied by spectroscopic and enzymatic method.