Related Experiment Video
Updated: Aug 10, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 16, 2013
Nuclear retinoid receptors: mediators of retinoid effects
1Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, Netherlands.
Abstract:
Nuclear receptors for retinoids were discovered in 1987 and appeared to belong to the superfamily of steroid/thyroid hormone receptors characterized by a common structure in which the different functions (trans-activation, DNA binding and ligand binding) are present in discrete modular domains in the protein. Retinoid receptors, however, are characterized by several unique features: a multiplicity of receptors and ligands, heterodimer formation and multiple direct repeats as response elements. All these mechanisms are exploited by retinoid receptors to fulfil their multiple tasks in controlling growth, development, differentiation and carcinogenesis.
More Related Videos
05:03Quantitative Analysis of Dietary Vitamin A Metabolites in Murine Ocular and Non-Ocular Tissues Using High-Performance Liquid Chromatography
Published on: December 27, 2024
08:18Methodology for Studying Interactions of Vitamin A Membrane Receptors and Opsin Protein with their Ligands in Generating the Retinylidene Protein
Published on: October 4, 2024
Related Concept Videos
Co-activators and Co-repressors
Nuclear Export
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
Directionality of Nuclear Transport
Regulation of Nuclear Protein Sorting
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes: