[Biosynthesis of renal prostaglandins in spontaneously hypertensive rats]

Biosynthesis of prostaglandins E2 and F2alpha from the exogenously added 14C-arachidonic acid in the renal medulla of spontaneously hypertensive (SHR) and normotensive Wistar rats (1 1/2- and 3 1/2-months-old) was studied. Investigations carried out showed that the formation of PgE2 from the arachidonic acid by the kidneys of SHR was significantly lower than in Wistar rats, whereas biosynthesis of PgF2alpha was practically normal. No difference in the prostaglandin-synthetase activity was noted in the kidneys of SHR of different age, whereas Wistar rats displayed a reduction of the PgE2 synthesis by the age of 3 1/2 months.