[Effect of sigetin on anovulation in rats]

The effect of sygethin on anovulatory cycle was studied in mature female rats. Anovulation was experimentally induced in rats on the one hand by stress effect (keeping rats in crowded conditions), and on the other hand by removing one ovary (hemicastration). Sygethin therapy (10 mg/kg for 4-5 days) proved to restore normal ovulation. When higher sygethin doses were used, and when it was administered for longer periods (for 2 to 3 weeks) no such effect proved to ensue. The results of these experiments suggest that small doses of sygethin stimulated luteinizing hormone secretion.