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Updated: Aug 10, 2026
14:56
An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
Published on: January 27, 2010
Analgesic efficacy of controlled-release oxycodone in postoperative pain
A Sunshine1, N Z Olson, A Colon
1Department of Medicine, New York University Medical Center, Analgesic Development Ltd., New York 10021-3522, USA.
Journal of Clinical Pharmacology
|July 1, 1996
Summary
Controlled-release oxycodone demonstrated safety and efficacy for post-surgical pain management. Higher doses showed improved pain relief and longer duration compared to immediate-release formulations.
Area of Science:
- Pharmacology
- Pain Management
- Clinical Trials
Background:
- Post-surgical pain requires effective and safe analgesic options.
- Controlled-release (CR) oxycodone offers a potential alternative to immediate-release (IR) formulations.
- Optimizing analgesic regimens is crucial for patient recovery.
Purpose of the Study:
- To compare the efficacy and safety of graded doses of CR oxycodone against IR oxycodone, oxycodone/acetaminophen, and placebo.
- To evaluate dose-response relationships for CR oxycodone in managing post-operative pain.
- To assess the onset, peak effect, and duration of pain relief for different oxycodone formulations.
Main Methods:
- Single-dose, double-blind, randomized, parallel-group study.
- 182 inpatients with moderate to severe post-abdominal/gynecologic surgery pain.
- Hourly pain intensity and relief ratings for 12 hours post-administration.
Main Results:
- All active treatments significantly outperformed placebo.
- CR oxycodone showed a dose-response effect, with 20 and 30 mg superior to 10 mg.
- CR oxycodone provided longer pain relief (10-12 hours) than IR oxycodone or oxycodone/acetaminophen (approx. 7 hours).
- Adverse events, like somnolence, were observed across active treatment groups.
Conclusions:
- CR oxycodone is a safe and effective option for managing moderate to severe post-surgical pain.
- The prolonged duration of action of CR oxycodone offers potential benefits for pain management.
- Further investigation into CR oxycodone's characteristics may enhance post-operative pain treatment strategies.
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