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Related Experiment Videos

Delayed-type hypersensitivity skin testing: normal values in the Australian population

C Hickie1, I Hickie, D Silove

  • 1Mood Disorders Unit, Prince Henry Hospital, Little Bay, NSW, Australia.

International Journal of Immunopharmacology
|August 1, 1995
PubMed
Summary
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This study found that cell-mediated immunity (CMI) test responses in healthy Australians differ from international norms. Researchers should use caution when interpreting CMI Multitest results in this population.

Area of Science:

  • Immunology
  • Psychoimmunology

Background:

  • Standardized cell-mediated immunity (CMI) Multitest system assesses delayed-type hypersensitivity (DTH) skin responses.
  • Limited normative data exists for the Australian population, particularly concerning geographical variations and differing exposure rates.
  • Previous standardization focused on males, while many patient cohorts are female.

Purpose of the Study:

  • To establish normative values for the CMI Multitest in a healthy Australian population.
  • To compare Australian DTH responses with international data.
  • To investigate potential differences in CMI responses between males and females in Australia.

Main Methods:

  • Utilized the standardized CMI Multitest system.
  • Assessed DTH skin responses to ubiquitous antigens in medically and psychologically healthy Australian males (n=66) and females (n=53).

Related Experiment Videos

  • Analyzed percentage of positive responses, mean number of positive responses, and mean induration diameter.

    • Main Results:

    • Positive response rates to individual antigens were similar to other Australian studies but lower than international reports.
    • Mean number of positive responses: 3.7 (men) vs. 2.8 (women).
    • Mean induration diameter: 17.5 mm (men) vs. 12.2 mm (women). Anergy and hypoergy rates were also reported.

    Conclusions:

    • The pattern of response to the CMI Multitest differs in healthy Australians compared to international populations.
    • Researchers must exercise caution when selecting samples, applying the test, and reporting results, emphasizing dimensional scores.
    • Consider geographical location, age, immunization, and disease exposure when interpreting CMI test results in Australians.