Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perinatal morphine II: changes in cortical plasticity

E Germani1, E Lesma, S De Biasi

  • 1Department of Medical Pharmacology, University of Milan, Italy.

Journal of Neuroscience Research
|December 15, 1995
PubMed
Summary

Perinatal morphine exposure hinders brain plasticity by inhibiting compensatory nerve growth after injury. This impairment affects serotonin and norepinephrine pathways, crucial for neural repair and function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebrospinal fluid kappa and lambda free light chains in oligoclonal band-negative patients with suspected multiple sclerosis.

European journal of neurology·2019
Same author

EPO-releasing neural precursor cells promote axonal regeneration and recovery of function in spinal cord traumatic injury.

Restorative neurology and neuroscience·2017
Same author

Ageing and inflammation in patients with HIV infection.

Clinical and experimental immunology·2016
Same author

p-Cresol and Cardiovascular Risk in Kidney Transplant Recipients.

Transplantation proceedings·2015
Same author

Two cases of successful efavirenz desensitization in patients with several anti-HIV drugs hypersensitivities.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia·2015
Same author

Dynamics of adaptive and innate immunity in patients treated during primary human immunodeficiency virus infection: results from Maraviroc in HIV Acute Infection (MAIN) randomized clinical trial.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2015

Area of Science:

  • Neuroscience
  • Neuroplasticity
  • Developmental Neuroscience

Background:

  • Perinatal morphine exposure is known to impair reactive plasticity in serotonin (5-HT) neurons.
  • Neural plasticity, the brain's ability to reorganize, is vital for recovery after injury.

Purpose of the Study:

  • To investigate the effect of perinatal morphine exposure on the compensatory sprouting of intact axons after partial denervation.
  • To determine if morphine affects the neurochemical adaptations in the frontal cortex following norepinephrine depletion.

Main Methods:

  • Neonatal 6-hydroxydopamine (6-OHDA) injection was used to deplete norepinephrine (NE) in the frontal cortex of rats.
  • Rats were exposed to morphine perinatally.
  • Neurochemical content (dopamine, 5-HT, met-enkephalin) and axon density (tyrosine hydroxylase, 5-HT) were analyzed.

Related Experiment Videos

Main Results:

  • Neonatal 6-OHDA induced compensatory increases in dopamine, serotonin, and met-enkephalin in the frontal cortex of control rats.
  • These compensatory changes were associated with increased tyrosine hydroxylase- and 5-HT-positive axon density.
  • In rats exposed to morphine perinatally, these compensatory neurochemical and structural changes were absent after 6-OHDA treatment.

Conclusions:

  • Perinatal morphine exposure inhibits the compensatory sprouting of intact axons following partial denervation.
  • Morphine exposure prevents the adaptive neurochemical changes in the frontal cortex that normally occur after norepinephrine depletion.
  • These findings highlight a critical window during development where opioid exposure can disrupt fundamental mechanisms of brain plasticity and recovery.