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Related Experiment Videos

Nortriptyline-induced hepatic failure

A M Pedersen1, H K Enevoldsen

  • 1Department of Medicine, Sundby Hospital, Copenhagen, Denmark.

Therapeutic Drug Monitoring
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

Nortriptyline, a common antidepressant, can cause liver injury even at therapeutic doses. Symptoms like hepatitis and elevated liver enzymes resolved after discontinuing the medication.

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Area of Science:

  • Hepatology
  • Clinical Pharmacology
  • Toxicology

Background:

  • Nortriptyline is a tricyclic antidepressant widely prescribed for depression.
  • Drug-induced liver injury (DILI) is a significant concern in pharmacotherapy.
  • Hepatotoxicity associated with tricyclic antidepressants is rare but documented.