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Activity of nitric oxide-generating compounds against encephalomyocarditis virus
E Guillemard1, M Geniteau-Legendre, R Kergot
1Laboratoire de Virologie et Immunologie Expérimentales, Centre d'Etudes Pharmaceutiques de Châtenay-Malabry, France.
Antimicrobial Agents and Chemotherapy
|April 1, 1996
Abstract:
Nitric oxide (NO) generated by two NO donors (sodium nitroprusside or S-nitroso-L-glutathione) was shown to exert a dose-dependent inhibition of encephalomyocarditis virus growth in L-929 cells. This activity was not due to the cytotoxic or direct virucidal effects of NO donors. L-929 cells were shown to produce NO endogenously, but this low level of production did not counter encephalomyocarditis virus replication.