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Bezoars: implicated drugs and avoidance strategies

K C Thompson1, J P Iredale

  • 1University of Southampton, England.

Drug Safety
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

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Certain medications can cause bezoar formation, a rare but serious condition. Awareness is crucial for clinicians, especially in elderly patients with comorbidities, to prevent complications.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Clinical Medicine

Background:

  • Bezoars are indigestible masses that can form in the gastrointestinal tract.
  • Drug-induced bezoars are an uncommon but significant clinical concern.
  • Predisposing factors are often present in patients who develop bezoars.

Purpose of the Study:

  • To identify drugs and drug classes associated with bezoar formation.
  • To raise clinician awareness of drug-induced bezoars.
  • To emphasize the importance of considering bezoars in susceptible patient populations.

Main Methods:

  • Literature review of drugs implicated in bezoar formation.
  • Clinical case analysis of patients presenting with bezoars.
  • Identification of common predisposing factors.

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Main Results:

  • A variety of medications have been linked to bezoar development.
  • Elderly patients and those with serious coexistent diseases are particularly susceptible.
  • Bezoars can be challenging to diagnose, often requiring surgical intervention.

Conclusions:

  • Clinicians must be aware of the potential for drug-induced bezoars.
  • Early recognition and diagnosis are critical, especially in vulnerable individuals.
  • Bezoars are associated with substantial patient morbidity and mortality.