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Related Experiment Videos

Current status in extracorporeal immunomodulation: immune disorders

T Bosch1

  • 1Nephrological Department, Klinikum Grosshadern, University of Munich, Germany.

Artificial Organs
|August 1, 1996
PubMed
Summary

Extracorporeal immunomodulatory procedures (ECIM) offer diverse methods to treat autoimmune diseases by removing harmful substances and modifying immune cells. These advanced therapies target pathogenic antibodies and immune complexes, aiding in patient recovery.

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Area of Science:

  • Immunology
  • Nephrology
  • Rheumatology

Background:

  • Clinicians utilize various extracorporeal immunomodulatory procedures (ECIM).
  • ECIM encompasses plasma exchange, double filtration, immunoadsorption, chemoadsorption, photopheresis, and cytoapheresis.
  • These procedures aim to modulate the immune system for therapeutic benefit.

Purpose of the Study:

  • To outline the mechanisms of extracorporeal immunomodulation (ECIM).
  • To highlight clinical applications and examples of ECIM.
  • To provide a comprehensive overview of current ECIM techniques.

Main Methods:

  • Removal of pathogenic antibodies and circulating immune complexes.
  • Reticuloendothelial system deblockage.
  • Modification of immune complex structure and cellular components like lymphocyte subsets.

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Main Results:

  • ECIM mechanisms include direct removal of immune effectors.
  • Altering antigen/antibody ratios and complement activation modulates immune complexes.
  • Cellular components, such as lymphocyte subsets, can be modified.

Conclusions:

  • ECIM offers a range of therapeutic options for immune-mediated diseases.
  • Mechanisms involve removing pathological substances and modulating immune responses.
  • Clinical examples demonstrate ECIM's utility in conditions like lupus erythematosus and myasthenia gravis.