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Saponins as vaccine adjuvants
1Cambridge Biotech Corporation, Worcester, MA 01605, USA.
Critical Reviews in Therapeutic Drug Carrier Systems
|January 1, 1996
Abstract:
Naturally occurring triterpene glycosides (saponins) from Quillaja saponaria have considerable adjuvant activity. Adjuvant functions include stimulation of high levels of antibody to T-dependent and T-independent antigens, induction of mouse IgG1, IgG2b, and IgG2a isotypes, and induction of cytotoxic T lymphocyte responses. This article reviews responses due to specific saponins of saponin preparations, effect of formulation, structure/function studies, and use in different preclinical and clinical vaccine applications.