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Related Experiment Videos

Prostate-specific antigen and prostatitis in men under fifty

V Pansadoro1, P Emiliozzi, L Defidio

  • 1Department of Urology, S. Camillo Hospital, Rome, Italy.

European Urology
|January 1, 1996
PubMed
Summary

Prostatitis can elevate prostate-specific antigen (PSA) levels, even in younger men without prostate cancer. Doctors should consider prostatitis when interpreting elevated PSA test results.

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Area of Science:

  • Urology
  • Andrology
  • Biochemistry

Background:

  • Prostate-specific antigen (PSA) is a key biomarker for prostate health.
  • Elevated PSA levels often prompt further investigation for prostate cancer.
  • The influence of prostatitis on PSA levels requires careful consideration.

Purpose of the Study:

  • To investigate the prevalence of elevated PSA serum concentrations in patients diagnosed with prostatitis.
  • To assess PSA levels in a population with a low incidence of benign prostatic hyperplasia and prostate cancer.
  • To determine the relationship between different types of prostatitis and PSA levels.

Main Methods:

  • PSA levels were measured in 72 male patients under 50 years of age with prostatitis.
  • Patients were categorized based on their prostatitis diagnosis: acute, chronic bacterial, chronic abacterial, and prostatodynia.

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  • PSA levels were compared against a threshold of 4 ng/ml.

    • Main Results:

    • Elevated PSA (> 4 ng/ml) was observed in 71% of patients with acute prostatitis.
    • 15% of patients with chronic bacterial prostatitis and 6% with chronic abacterial prostatitis showed elevated PSA.
    • No patients diagnosed with prostatodynia had elevated PSA levels.
    • Effective antibiotic therapy led to normalization of PSA levels in most patients with bacterial prostatitis.

    Conclusions:

    • Prostatitis is a significant factor that can cause elevated PSA levels.
    • PSA should not be solely interpreted as a marker for prostate cancer, especially in the presence of prostatitis.
    • Clinical evaluation for prostatitis is essential when interpreting elevated PSA results.