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Leukemoid reaction in epidermal squamous cell carcinoma
T Kiyosawa1, S Hirano, J Nakamura
1Department of Dermatology, Jichi Medical School, Tochigi.
The Journal of Dermatology
|August 1, 1996
Summary
This case report details a rare leukemoid reaction linked to squamous cell carcinoma of the skin. The reaction was initially caused by tumor invasion of bone and later by severe sepsis.
Area of Science:
- Oncology
- Hematology
Background:
- Leukemoid reactions are typically associated with non-neoplastic conditions.
- Cutaneous squamous cell carcinoma rarely presents with leukemoid reactions.
Observation:
- A patient presented with epidermal squamous cell carcinoma of the sacral region, invading the sacrum and coccyx.
- The patient exhibited a leukemoid reaction with a white blood cell count exceeding 20,000/mm³.
- Post-operative sepsis from Staphylococcus aureus and Bacteroides caccae further elevated leukocyte counts.
Findings:
- This is the first reported case of a leukemoid reaction associated with cutaneous squamous cell carcinoma.
- The leukemoid reaction was attributed to direct bone invasion by the tumor and subsequent severe infection.
Implications:
- Highlights a rare paraneoplastic phenomenon associated with advanced cutaneous squamous cell carcinoma.
- Emphasizes the importance of considering infection in the differential diagnosis of leukemoid reactions in cancer patients.