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Pharmacological characterization of glial cell line-derived neurotrophic factor (GDNF): implications for GDNF as a

P A Lapchak1, S Jiao, P J Miller

  • 1AMGEN Inc., Department of Neuroscience, MC 5-1-C, 1840 de Havilland Drive, Thousand Oaks, CA 91320-1789, USA. plapchak@amgen.com

Cell and Tissue Research
|November 1, 1996
PubMed

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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...