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A simple light-driven transmembrane proton pump

K Sun1, D Mauzerall

  • 1Rockefeller University, New York, NY 10021, USA.

Proceedings of the National Academy of Sciences of the United States of America
|October 1, 1996
PubMed
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This study demonstrates a light-driven, proteinless proton pump using porphyrin molecules and weak acids to create energy transfer across lipid bilayers, mimicking biological pumps.

Area of Science:

  • Biophysical Chemistry
  • Membrane Biophysics
  • Bioenergetics

Background:

  • Lipid bilayers are crucial for cellular energy transduction.
  • Artificial systems can model biological processes like proton pumping.
  • Proton carriers facilitate ion transport across membranes.

Purpose of the Study:

  • To investigate light-induced proton pumping across a lipid bilayer.
  • To explore the role of hydrophobic weak acids as proton carriers.
  • To model a prebiological energy transducer.

Main Methods:

  • Utilizing lipophilic porphyrins and aqueous acceptors for charge separation.
  • Employing carbonylcyanide m-chlorophenylhydrazone analogues as proton carriers.
  • Measuring currents, voltages, and D2O isotope effects.

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Main Results:

  • Observed light-induced proton pumping across a lipid bilayer.
  • Identified reversed currents and voltages driven by photoformed ions.
  • Confirmed proton movement via a significant D2O isotope effect.
  • Achieved an estimated pumping efficiency of 10-30%.

Conclusions:

  • An interfacial pK shift induced by local electric fields drives proton pumping.
  • The light-driven system functions on a millisecond timescale, similar to biological pumps.
  • This proteinless pump serves as a model for early biological energy transduction.