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Related Experiment Videos

Factitious Cushing syndrome

G Cizza1, L K Nieman, J L Doppman

  • 1Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892-1262, USA.

The Journal of Clinical Endocrinology and Metabolism
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

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Factitious Cushing syndrome is rare and difficult to diagnose. High-performance liquid chromatography (HPLC) analysis of urine steroids is the definitive test for identifying glucocorticoid abuse in suspected cases.

Area of Science:

  • Endocrinology
  • Clinical Diagnostics

Background:

  • Factitious Cushing syndrome is infrequently reported.
  • This study aimed to characterize clinical and laboratory features of factitious Cushing syndrome.

Observation:

  • Six patients (5 female, 1 male, ages 31-44) with factitious Cushing syndrome were identified retrospectively.
  • Patients often had prior surgeries, history of depression/anxiety, and some had medical contact or drug abuse history.
  • Physical Cushing syndrome signs were variable; laboratory results showed inconsistent urine-free cortisol (UFC) and 17-hydroxysteroid (17-OHCS) levels.

Findings:

  • Imaging studies (CT, MRI) of adrenal and pituitary glands were inconclusive for factitious disorder.
  • High-performance liquid chromatography (HPLC) analysis for synthetic glucocorticoids was positive in all tested patients.

Related Experiment Videos

  • HPLC is the most definitive test for factitious Cushing syndrome.

    • Implications:

    • Early identification of factitious Cushing syndrome can prevent unnecessary surgeries and treatments.
    • HPLC testing should be considered in patients with suspected glucocorticoid abuse.
    • This aids in efficient diagnosis and resource allocation for hypercortisolism evaluations.