Pharmacological studies on Lepidium sativum, linn

Area of Science:

• Pharmacology
• Cardiovascular Science
• Ethnobotany

Background:

• Lepidium sativum, commonly known as garden cress, has a history of traditional medicinal use.
• Preliminary observations suggested potential cardiovascular effects of Lepidium sativum extracts.

Purpose of the Study:

• To investigate the pharmacological properties of a cardioactive substance isolated from Lepidium sativum.
• To elucidate the mechanism of action and stability of this cardioactive compound.

Main Methods:

• Pharmacological assays were conducted to assess the effects of the substance on cardiovascular parameters.
• Stability studies were performed in solution.
• Tachyphylaxis was evaluated through repeated administration.

Main Results:

• A cardioactive substance was identified in Lepidium sativum.
• The substance demonstrated instability in solution.
• Progressive decrease in response upon repeated administration (tachyphylaxis) was observed.
• Evidence suggests the substance acts through adrenergic mechanisms.

Conclusions:

• Lepidium sativum possesses a cardioactive compound with specific pharmacological characteristics.
• The compound's instability and tachyphylaxis suggest complex interactions.
• Adrenergic pathways are likely involved in its cardiovascular effects.