Brain levels of chloradiazepoyide in rats

The time-and dose-dependent uptake of chlordiazepoxide by the brain of rats was investigated and correlated with the blood levels of the drug. Peak concentration in the brain was reached in 10 min after i.p. injection of 25 mg/kg, and in 5 min with a dose of 50 mg/kg of the drug. Retention of chlordiazepoxide by the brain showed different characteristics dependeing on the size of the dose used.