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The release of kininase from rat isolated hearts during myocardial ischaemia
M Ahmad1, I J Zeitlin, J R Parratt
1Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland, UK.
Immunopharmacology
|June 1, 1996
Abstract:
BK destroying activity was observed in rat isolated heart perfusates. BK was optimally degraded at pH 8.4 in rat heart. The results indicated that myocardial kinin degradation was due to ACE and a serine protease. These results suggest that bradykinin may have some cardioprotective role during myocardial ischaemia at acidic pH.