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Related Experiment Videos

Varicella-zoster virus. The virus

J I Cohen1

  • 1National Institutes of Health, Bethesda, Maryland, USA.

Infectious Disease Clinics of North America
|September 1, 1996
PubMed
Summary

Varicella-zoster virus (VZV) causes chickenpox and shingles. This virus can remain dormant in nerve cells for life, with limited protein expression during latency.

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Area of Science:

  • Virology
  • Neuroscience

Background:

  • Varicella-zoster virus (VZV) is responsible for chickenpox and herpes zoster (shingles).
  • Following initial infection, VZV establishes lifelong latency within the dorsal root and trigeminal ganglia.
  • The VZV genome encodes approximately 70 proteins, with at least three implicated in human latency.

Purpose of the Study:

  • To investigate the characteristics of Varicella-zoster virus latency.
  • To understand the viral proteins expressed during the latent phase of VZV infection.

Main Methods:

  • Analysis of VZV genome and protein expression during latency.
  • Cell culture studies to assess VZV replication and characteristics.

Main Results:

  • VZV establishes lifelong latency in neural ganglia.
  • Limited expression of VZV proteins occurs during latency.
  • VZV is highly cell-associated, making high-titer cell-free virus production challenging.

Conclusions:

  • Understanding VZV latency is crucial for managing VZV-associated conditions.
  • Further research into VZV latency mechanisms may reveal therapeutic targets.

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