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[A new embolic material: super absorbent polymer (SAP) microsphere and its embolic effects]
Y Jiaqi1, S Hori, K Minamitani
1Department of Radiology, Osaka University, Medical School.
Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiologica
|January 1, 1996
Summary
SAP-Microspheres, a sodium acrylic acid-vinyl alcohol copolymer, effectively occlude blood vessels and show no recanalization in rabbit kidneys. These promising embolic agents maintain shape and offer fluoroscopic visibility for embolization therapy.
Area of Science:
- Biomaterials Science
- Vascular Interventional Radiology
Context:
- Embolization therapy requires effective occlusive agents.
- Current agents may have limitations in control and visibility.
Purpose:
- To evaluate SAP-Microspheres (sodium acrylic acid-vinyl alcohol copolymer) as a potential embolic agent.
- To assess the efficacy and biocompatibility of SAP-Microspheres in a preclinical model.
Summary:
- SAP-Microspheres absorb fluids, swelling to calibrated sizes (2.1x in contrast, 3.5x in serum) and passing through microcatheters.
- In rabbit kidney embolization (n=10), no recanalization occurred over 1-14 weeks.
- The microspheres maintained spherical integrity, showed minimal inflammatory response, and induced fibrosis and calcification by 4 weeks.
Impact:
- SAP-Microspheres demonstrate potential as a safe and effective embolic agent.
- The study supports their use in embolization procedures with satisfactory outcomes.
- Fluoroscopic visibility and controlled swelling offer procedural advantages.