Related Experiment Videos
Antireflux operations at flexible endoscopy using endoluminal stitching techniques: an experimental study
S S Kadirkamanathan1, D F Evans, F Gong
1Gastrointestinal Science Research Unit, London Hospital Medical College, United Kingdom.
Gastrointestinal Endoscopy
|August 1, 1996
Summary
Endoscopic antireflux operations like gastroplasty, fundoplication, and anterior gastropexy were successfully performed in dogs using novel suturing techniques. This minimally invasive approach shows promise for treating reflux without traditional surgery.
Area of Science:
- Gastroenterology
- Minimally Invasive Surgery
- Endoscopic Procedures
Background:
- Traditional antireflux surgeries often require laparotomy or laparoscopy.
- Novel endoscopic techniques offer less invasive alternatives.
Purpose of the Study:
- To evaluate the feasibility of performing antireflux operations (gastroplasty, fundoplication, anterior gastropexy) using flexible endoscopy.
- To assess the safety and efficacy of endoluminal suturing techniques for reflux treatment.
Main Methods:
- Utilized an endoscopic sewing machine, knotting devices, overtube, and nylon thread in adult beagle dogs.
- Performed gastroplasty, fundoplication, and anterior gastropexy via flexible endoscopy.
- Assessed suture integrity and functional outcomes using repeat endoscopy and manometry.
Main Results:
- All three antireflux operations were successfully performed without mortality.
- Sutures remained visible in 90% of cases at 4-8 week follow-up.
- Significant increases in lower esophageal sphincter pressure (4.6 to 13.33 mm Hg) and cardiac yield pressure (10 to 19 mm Hg) were observed post-procedure.
Conclusions:
- Antireflux operations can be feasibly performed using flexible endoscopy and endoluminal suturing.
- This minimally invasive approach avoids the need for laparoscopy or laparotomy.
- The demonstrated techniques show potential for a new class of endoscopic gastrointestinal surgery.