An uncommon presentation of Salmonella

A Deutsch1, D Wasserman, E Ruchelli

  • 1Children's Hospital of Philadelphia, Division of Gastroenterology, PA 19104, USA.

Insights

Salmonella infection can mimic appendicitis, making diagnosis difficult. Consider enteric infections in children with unusual appendicitis symptoms to guide appropriate management.

Area of Science:

  • Pediatric infectious diseases
  • Gastrointestinal pathology

Background:

  • Salmonella infection can present as appendicitis or mimic its symptoms through inflammation of the appendix, ileum, or lymph nodes.
  • Distinguishing Salmonella-induced inflammation from acute appendicitis can be challenging based on clinical, radiologic, and laboratory findings alone.

Observation:

  • A case study of a child with an atypical Salmonella presentation requiring diagnostic laparotomy highlights the overlap between enteric infections and acute appendicitis.
  • A literature review revealed diverse clinical presentations in patients with suspected appendicitis and positive Salmonella cultures.

Findings:

  • Salmonella infection presents a diagnostic challenge in appendicitis cases, with varied clinical manifestations.
  • Clinical and diagnostic evaluations may not reliably differentiate Salmonella appendicitis from other causes.

Implications:

  • Enteric infections, particularly Salmonella, should be considered in pediatric patients presenting with atypical appendicitis symptoms.
  • Awareness of Salmonella's potential to cause or mimic appendicitis is crucial for guiding clinical management when appendicitis signs develop.

Related Concept Videos

Reservoir of Infection01:30

Reservoir of Infection

Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...