Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of mesangial matrix after immunosuppressive therapy in children with reversible membranoproliferative

S Inaba1, T Tanizawa, T Takahashi

  • 1Department of Pediatrics, Toyama Medical and Pharmaceutical University, Japan.

Clinical Nephrology
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vox Sanguinis International Forum on donor notification and counselling strategies for markers of transfusion-transmissible infections.

Vox sanguinis·2017
Same author

Vox Sanguinis International Forum on donor notification and counselling strategies for markers of transfusion-transmissible infections: summary.

Vox sanguinis·2017
Same author

Comparison of neutralization profiles for anti-HCV reactive donor samples with or without detectable HCV RNA.

Vox sanguinis·2015
Same author

A novel mutation of the GATA site in the erythroid cell-specific regulatory element of the ABO gene in a blood donor with the Am B phenotype.

Vox sanguinis·2015
Same author

A new transfectant panel cell line-based MoAb-independent antigen capture assay system for detection of CD36 antibody.

Vox sanguinis·2014
Same author

Significant background rates of HBV and HCV infections in patients and risks of blood transfusion from donors with low anti-HBc titres or high anti-HBc titres with high anti-HBs titres in Japan: a prospective, individual NAT study of transfusion-transmitted HBV, HCV and HIV infections.

Vox sanguinis·2011

Immunosuppressive therapy improved kidney function in children with membranoproliferative glomerulonephritis (MPGN) type I. Mesangial matrix expansion decreased, correlating with clinical recovery and reduced extracellular matrix staining.

Area of Science:

  • Pediatric Nephrology
  • Glomerular Diseases
  • Immunopathology

Background:

  • Membranoproliferative glomerulonephritis (MPGN) type I is a significant cause of kidney disease in children.
  • Abnormal urinary findings and impaired renal function are common at diagnosis.
  • Understanding the long-term impact of immunosuppressive therapy is crucial for pediatric nephrology.

Purpose of the Study:

  • To evaluate the long-term clinical and histological course of childhood MPGN type I after immunosuppressive therapy.
  • To assess changes in mesangial matrix expansion and extracellular matrix deposition.
  • To correlate histological findings with clinical recovery.

Main Methods:

  • Longitudinal follow-up of 10 children diagnosed with MPGN type I.

Related Experiment Videos

  • Analysis of serial renal biopsies including morphometry (mesangial matrix to glomerular area ratio - M/G%) and extracellular matrix staining (collagens, fibronectin).
  • Correlation of histological parameters with clinical outcomes (urinalysis, renal function).

    • Main Results:

    • Significant improvement in urinalysis and renal function in most patients after a mean follow-up of 14 years.
    • Initial increase in M/G% at diagnosis, followed by a significant decrease in repeat biopsies in several patients.
    • Increased deposition of type IV collagen, type V collagen, and fibronectin in the mesangium, correlating with M/G%.

    Conclusions:

    • Childhood MPGN type I can have a reversible clinical course with immunosuppressive treatment.
    • Decreased mesangial matrix expansion and extracellular matrix deposition parallel clinical improvement.
    • Histological assessment of mesangial matrix changes provides insights into disease activity and treatment response.